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《遵义医科大学学报》[ISSN:1000-9035/CN:22-1262/O4]

卷:

期数:

2022年02期

页码:

270-276

栏目:

综述

出版日期:

2022-04-25

文章信息/Info

Title:

Research and application progress of bacteriophage in colorectal cancer

文章编号:

2096-8159(2022)02-0270-07

作者:

郑书娟; 肖建辉

(遵义医科大学附属医院,遵义市医药生物技术重点实验室,贵州 遵义 563099)

Author(s):

Zheng Shujuan; Xiao Jianhui

(Zunyi Municipal Key Laboratory of Medicinal Biotechnology,Affiliated Hospital of Zunyi Medical University,Zunyi Guizhou 563099,China)

关键词:

噬菌体;  结直肠癌;  肠道微生物

Keywords:

bacteriophage;  colorectal cancer;  intestinal microbes

分类号:

R735.3

DOI:

-

文献标志码:

A

摘要:

肠道微生物与健康和疾病有密切关系,是近20年来生物医学领域的研究热点。这些研究大多聚焦于肠道细菌,但实际上肠道病毒,特别是噬菌体亦具有重要研究价值。噬菌体是一类专一感染细菌的病毒,是人体肠道微生物组的重要组成部分,种类丰富、数量巨大,其可通过塑造肠道菌群结构,进而影响人体健康。近些年的研究结果提示,噬菌体种群的改变可影响结直肠癌的发生发展。本文搜集了近年来有关结直肠癌与噬菌体相关研究的文献,就噬菌体的功能及其与细菌间的相互作用、肠道噬菌体在结直肠癌发生发展中的作用、特异性噬菌体在结直肠癌中的应用等3个方面进行了综述,为结直肠癌的防治提供新思路。

Abstract:

Intestinal microbes are closely related to health and disease,and have become a research hotspot in the field of biomedicine in the past two decades.Most of these studies focused on intestinal bacteria.However,enteroviruses,especially bacteriophages,also actually have an important research value.Bacteriophages are a type of virus that specifically infects bacteria and an important part of the human intestinal microbiome with rich in variety and large in number,and deeply impact on human healthy altering the structure of the intestinal flora.Research results in recent years have suggested that changes in the phage population can affect the occurrence and development of colorectal cancer.To provide a new idea for the prevention and treatment of colorectal cancer,in this paper we collected major literatures involving the relationship between colorectal cancer and bacteriophage in recent years,and outlined the function of bacteriophage and its interaction with bacteria,the role of intestinal bacteriophage in the occurrence and development of colorectal cancer,and the application of specific phages in colorectal cancer.

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备注/Memo

备注/Memo:

[基金项目]国家自然科学基金资助项目(NO:81460156); 国家高层次人才特殊支持计划(NO:国科发资[2018]29); 贵州省高层次创新性人才支持计划(NO:黔科合人才[2015]4028)。
[通信作者]肖建辉,男,博士,教授,硕士生导师,研究方向:干细胞化学生物学与微生物天然药学发现的研究,E-mail:jhxiao@zmu.edu.cn。

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更新日期/Last Update: 1900-01-01