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 Zheng Shujuan,Xiao Jianhui.Research and application progress of bacteriophage in colorectal cancer[J].Journal of Zunyi Medical University,2022,(02):270-276.





Research and application progress of bacteriophage in colorectal cancer
(遵义医科大学附属医院,遵义市医药生物技术重点实验室,贵州 遵义 563099)
Zheng ShujuanXiao Jianhui
(Zunyi Municipal Key Laboratory of Medicinal Biotechnology,Affiliated Hospital of Zunyi Medical University,Zunyi Guizhou 563099,China)
噬菌体 结直肠癌 肠道微生物
bacteriophage colorectal cancer intestinal microbes
Intestinal microbes are closely related to health and disease,and have become a research hotspot in the field of biomedicine in the past two decades.Most of these studies focused on intestinal bacteria.However,enteroviruses,especially bacteriophages,also actually have an important research value.Bacteriophages are a type of virus that specifically infects bacteria and an important part of the human intestinal microbiome with rich in variety and large in number,and deeply impact on human healthy altering the structure of the intestinal flora.Research results in recent years have suggested that changes in the phage population can affect the occurrence and development of colorectal cancer.To provide a new idea for the prevention and treatment of colorectal cancer,in this paper we collected major literatures involving the relationship between colorectal cancer and bacteriophage in recent years,and outlined the function of bacteriophage and its interaction with bacteria,the role of intestinal bacteriophage in the occurrence and development of colorectal cancer,and the application of specific phages in colorectal cancer.


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[基金项目]国家自然科学基金资助项目(NO:81460156); 国家高层次人才特殊支持计划(NO:国科发资[2018]29); 贵州省高层次创新性人才支持计划(NO:黔科合人才[2015]4028)。
更新日期/Last Update: 1900-01-01