|本期目录/Table of Contents|

[1]徐荣佳,夏泽鲁,秦艺珊,等.中医外治法治疗甲状腺功能亢进及甲亢性突眼的临床疗效及安全性的Meta分析[J].遵义医科大学学报,2022,(02):231-241.
 Xu Rongjia,Xia Zelu,Qin Yishan,et al.Efficacy and safety of external treatment traditional chinese medicine on the treatment of hyperthyroidism and Graves’ orbitopathy:A meta-analysis[J].Journal of Zunyi Medical University,2022,(02):231-241.
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中医外治法治疗甲状腺功能亢进及甲亢性突眼的临床疗效及安全性的Meta分析()
     
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《遵义医科大学学报》[ISSN:1000-9035/CN:22-1262/O4]

卷:
期数:
2022年02期
页码:
231-241
栏目:
临床经验交流
出版日期:
2022-04-25

文章信息/Info

Title:
Efficacy and safety of external treatment traditional chinese medicine on the treatment of hyperthyroidism and Graves’ orbitopathy:A meta-analysis
文章编号:
2096-8159(2022)02-0231-11
作者:
徐荣佳1夏泽鲁1秦艺珊2靳方舟1姜 晨1
(1.天津中医药大学第一附属医院,国家针灸临床研究中心,天津 300384; 2.天津中医药研究院附属医院,天津 300120)
Author(s):
Xu Rongjia1Xia Zelu 1Qin Yishan2Jin Fangzhou1Jiang Chen1
(1.First Teaching Hospital of Tianjin University of Traditional Chinese Medicine,National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion,Tianjin 300193,China; 2.Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital,Tianjin 300120,China)
关键词:
针刺 中医外治法 甲状腺功能亢进 甲亢性突眼 Meta分析
Keywords:
Acupuncture external treatment of traditional Chinese medicine hyperthyroidism Graves’ orbitopathy Meta-analysis
分类号:
R246.6
DOI:
-
文献标志码:
B
摘要:
目的 系统评价针刺、穴位贴敷、耳穴贴压、中药雾化等中医外治法辅助治疗甲状腺功能亢进及甲亢性突眼的临床疗效及安全性。方法 检索1980年1月至2021年5月中国期刊全文数据库(CNKI)、维普中文期刊数据库(VIP)、万方数据库(WanFangData)、中国生物医学文献数据库(CBM)、PubMed等中英文数据库,收集有关针刺等中医外治法治疗甲状腺功能亢进及甲亢性突眼的临床对照试验。使用RevMan5.3软件进行Meta分析。结果 共纳入文献13篇1 223例患者,合并Meta分析结果显示,针刺等中医外治法在治疗甲状腺功能亢进及甲亢性突眼方面,相较于常规治疗,能够辅助改善患者甲状腺血清学指标FT3(P=0.000 5)、FT4(P=0.02),改善中医症候积分(P=0.000 4),以及减少常规药物治疗带来的不良反应(P=0.02); 在降低突眼度方面,亚组分析显示,针刺等中医外治法对病程<20个月的效果更佳(P<0.000 01),差异有统计学意义,但当大于20个月时,两者相比无统计学意义(P=0.05); 在升高TSH方面,亚组分析显示,针刺等中医外治法对病程>20个月的效果更佳,差异有统计学意义(P<0.000 01)。结论 基于现有数据可证明,针刺等中医外治法治疗甲状腺功能亢进及甲亢性突眼的临床效果优于单一常规疗法,尤其在改善突眼度、中医症候积分、降低常规药物带来的不良反应方面更为显著。
Abstract:
Objective To systematically evaluate the clinical efficacy and safety of external treatment of traditional Chinese medicine(ETCM)such as acupuncture,acupoint application,auricular pressure and herbal nebulization in the adjuvant treatment of hyperthyroidism and Graves orbitopathy(GO).Methods Data related to ETCM-based clinical controlled trials on hyperthyroidism and hyperthyroidism proptosis were searched on Chinese and English article databases including Chinese Journal Full-text Database(CNKI),VIP Chinese Journal Database(VIP),Wangfang Med Online(WangFang),China Biomedical Literature Database(CBM),and PubMed from January 1980 to May 2021.Meta-analysis was performed on RevMan 5.3.Results A total of 13 articles involving 1,223 patients were included.As revealed by the results of meta-analysis,in the treatment of hyperthyroidism and hyperthyroid proptosis,ETCM improved the thyroid serological indices(FT3 and FT4)(P=0.000 5,P=0.02)and the TCM syndrome score(P=0.0004)compared with conventional treatment,and mitigated the adverse effects of the latter( P=0.02).In terms of relieving exophthalmos,it was found from the subgroup analysis that ETCM was more effective in the treatment of diseases with the duration of fewer than 20 months( P<0.000 01); Conversely,there was not any difference when the disease with the duration of more than 20 months(P=0.51).Furthermore,in terms of increasing TSH,the subgroup analysis showed a contrary result in more than 20 months(P<0.000 01).Conclusion The collected data reveal that ETCM has a better clinical effect for hyperthyroidism and GO than conventional treatment,especially in improving exophthalmos and TCM symptoms,and reducing the adverse effects caused by conventional drugs.

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备注/Memo

备注/Memo:
[通信作者]姜晨,女,博士,副主任医师,博士生导师,研究方向:中医内科学,E-mail:jc82128@sina.com。
更新日期/Last Update: 1900-01-01